GENDER EFFECT ON ELECTIVE PERCUTANEOUS CORONARY INTERVENTION (PCI) OUTCOME IN ACUTE CORONARY SYNDROME

Abstract

Objective: This study examined the effect of female gender on Procedural success, in-hospital and six month adverse cardiac event rates following elective percutaneous coronary intervention in acute coronary syndrome. Methodology: This prospective, multi-center and descriptive study conducted at Karachi Pakistan from July 2010 to March 2012. A total 312 acute coronary syndrome (ACS) patients who underwent elective coronary angioplasty with stent were included in study. Patients underwent primary PCI were excluded. Procedure success defined as when there was less than 10% post-dilated stent stenosis without complication. In-hospital and six month follow up adverse event rates was the combined rate of death, myocardial infarction, stroke, heart failure, CABG or repeat PCI. Results: Compared with men with ACS (n=190,60.9%), women (n=122,39.1%) were older and more often had hypertension, diabetes mellitus, dyslipidemia, and unstable angina (p<0.001 for all), whereas multi-vessel disease was less frequent (p<0.01). Procedure success in male and female was 97.6% and 96.7% respectively. In-hospital mortality rates for elective PCI were low and comparable. In hospital and six months after the procedure there were no gender differences for cardiac death, myocardial infarction, or percutaneous revascularization for men and women, respectively. Conclusion: Women undergoing elective coronary angioplasty with stent for acute coronary syndrome have a higher baseline risk characteristics , whereas procedural success, in hospital and six month adverse event rates were similar.