Study of Serum Isoenzymes of Creatine Phosphokinase and Lactate Dehydrogenase in Myocardial Infarction

Abstract

INTRODUCTION: The serum enzymes, creatine phosphokinase, lactate dehydrogenase and aspartate aminot ransferase are measured routinely for the diagnos is of acute myocardial infarction in local hQspit als. It is well established that all the three enzym es are sensitive indicators of acute myocardial infarction. CPK level is raised however, in muscle diseases skeletal muscle injury (particularly I/M injections), brain damage, alcoholism, pulmon ary embolism and after cardioversion. PATIENTS AND METHODS: Ninety two patients suffering from acute myocardial infarction admitted to coronary care unit Mayo Hospital Lahore, were included in the study. The diagnosis of acute myocardial infarction was based on typical history, electroc ardiogram and serum enzyme and isoenzyme changes. RESULTS: The data was analysed by analysis of variance (F test) test. The results are shown in Table LVIII. DISCUSSION: The total serum CPK test has been advocated as an indicator of myocardial infarction (Smith, 1967), principally • because this enzyme is not found in the liver and erythrocytes (Colombo et al., 1962), both of them are common sources of error in infarct diagnosis by means of serum enzym tests. Keeping in mind the conditions in local hospitals, it is suggested that determination of both serum CKMB and HBDH should be carried out along with total enzyme level of serum CPK, LDH and SGOT for the proper diagnosis of acute myocardial infarction.