CORRELATION OF MEAN HBA1C LEVELS WITH SEVERITY OF CORONARY ARTERIES DISEASE IN DIABETICS

Abstract

Objective: The aim of this study was to know the correlation of mean HbA1c levels with severity of coronary arteries disease (CAD) in diabetics. Methodology: This descriptive cross sectional study was conducted at Punjab Institute of Cardiology, Lahore from May 2011 to November 2011 including 228 patients, 30 to 70 years of age with the diagnosis of ACS or stable angina and no contraindication to coronary angiography. HbA1c levels were measured in all patients. Severity of CAD was determined on the basis of number of coronary arteries involved and patients were divided into three groups i.e. mild, moderate and severe CAD. Mean HbA1c values were then compared in all three groups to determine the correlation HbA1c levels with severity of CAD. Results: The mean age of study population was 51.5±9.5 years. Males were 151(65.7%). Mild CAD patients were 89(38.7%), 71(30.9%) were moderate disease while 70(30.4%) had severe CAD. Hypertensive patients were 128(55.7%), 52(22.6%) were smokers, 82(35.7%) were dyslipidemic and 26(11.3%) patients had positive family history of premature CAD. Mean HbA1c of the study population was 9.1±1.02 (8.1±0.37 in mild CAD group, 9.1±0.50 in moderate and 10.3±0.53 in severe CAD group. Severity of coronary artery disease increases with increase in Hemoglobin A1c level(p<0.0001). Patients with high HbA1c levels have more number of coronaries diseased as compared to those who have lower levels. Conclusion: HbA1c is directly related to severity of coronary artery disease;the more the HbA1c level the more severe is the coronary artery disease.