Effect of Magnesium Sulfate with Propofol on Hemodynamic Stability during Tracheal Intubation in Patients Undergoing Coronary Artery Bypass Grafting: A Single-Center Study

Abstract

Objectives: This study aimed to assess the hemodynamic response of magnesium sulfate (MGS) with propofol during tracheal intubation in patients undergoing coronary artery bypass grafting (CABG). Methodology: A cross-sectional study was conducted at a tertiary cardiac center in Pakistan, involving 100 patients undergoing elective CABG. Hemodynamic parameters were recorded before and after intubation, following the administration of MGS with propofol. Results: The mean systolic blood pressure was 114.9±9.4 mmHg, 120.3±3.4 mmHg and 111.1±6.4 mmHg before intubation, after 2 minutes and 5minutes respectively, with p-value of <0.001. The mean diastolic blood pressure was 66.2±10.3 mmHg, 67.8±6.1 mmHg, and 62±7.2 mmHg before intubation, after 2 minutes and 5minutes respectively, with p-value of <0.001. The mean arterial blood pressure was 82.5±9.2 mmHg, 85.3±4.5, mmHg and 78.4±6.4 mmHg before intubation, after 2 minutes and 5minutes respectively, with p-value of <0.001. The mean heart rate was 65.1±8.8 bpm, 69.7±5.2 bpm and 71.3±4.6 bpm before intubation, after 2 minutes and 5minutes respectively, with p-value of <0.001. Conclusion: The study concludes that the addition of MGS to propofol contributes to hemodynamic stability during tracheal intubation in patients undergoing CABG. Further research is needed to validate these findings and explore optimal dosing regimens.