Factors Influencing Post-Thrombolytic ST-Segment Resolution in STEMI Patients: A Cross-Sectional Study from Tertiary Care Hospitals

Abstract

Objectives: This study aimed to evaluate the effectiveness of post-thrombolytic ST-segment resolution in patients with ST-elevation myocardial infarction (STEMI) and to identify factors associated with the resolution outcomes. Methodology: A cross-sectional study was conducted at Mardan Medical Complex and Bacha Khan Medical Complex Swabi. Electrocardiogram (ECG) of STEMI patients were reviewed to assess the resolution of ST-segment elevation after thrombolytic therapy. Complete resolution was defined as a ≥70% reduction in ST-segment elevation, partial resolution as a reduction between 30% and 70%, and failed resolution as a <30% reduction. Data were entered and analyzed using SPSS. Results: A total of 222 STEMI patients were included in the study, with 61.3% being male. The mean age of the participants was 57.9±10.8 years. After thrombolytic therapy, 27.5% of patients achieved complete ST-segment resolution, while 51.8% had partial resolution. The resolution of ST-segment elevation was significantly associated with a history of hypertension, but no significant association was found with diabetes mellitus, dyslipidemia, or renal disease. Conclusion: The rate of complete ST-segment resolution following thrombolytic therapy in STEMI patients was relatively low compared to partial resolution. Hypertension was significantly associated with the degree of ST-segment resolution, while diabetes mellitus, dyslipidemia, and renal disease did not significantly impact the resolution of ST-segment elevation in STEMI patients.