FACTS REVEALED; TOTAL/HIGH DENSITY LIPOPROTEIN CHOLESTEROL VALUES AND THEIR RATIO AMONG MACRO-VASCULAR COMPLICATIONS OF DIABETES

Abstract

Objectives: There is key concept that raised mortality among diabetics with stroke, peripheral vascular disease and particularly coronary artery diseases may be owing to dyslipidaemia and its prior detection is needed for timely prevention. Total /HDL cholesterol values and its ratio can be predictive tool among macro-vascular complications of diabetes. Methodology: A retrospective observational study was conducted in Alamgir Medical Services, airport road Bahawalpur; during a period of 6 months from 30-06-2021 to 30-12-2021.A quantitative data of 100 diabetics with macro-vascular complications were analysed. 52 patients with coronary artery disease (CAD) were identified as group A, 30 subjects had cerebro-vascular accident (CVA) and labelled as group B while 18 patients with peripheral vascular disease (PVD) as group C. Values of lipoproteins and main outcome measure of TC: HDLC ratio were compared between the three groups accordingly. Results: In patients with CAD, the mean (SD) concentration of total cholesterol (TC) was 220.08(27.9) mg/dl, HDL – C was 34.8 (6.2) mg/dl while TC: HDLC ratio was > 6 and in high risk range (normal ratio should be < 5). Both lipoproteins (TC and HDL and their ratio) were observed within normal range in group B (CVA) as mean SD 180.68(23.4) mg/dl and 35.09(6.9) mg/dl respectively, and in group C (PVD) as 160.20(19) mg/dl and 40.6(5.4) mg/dl respectively. Conclusion: Diabetics having CAD have raised TC: HDL C ratio and there is advantage to use this ratio for predicting CAD risk.