Bisoprolol: A Nçw Cardioselective Beta Blocker In Hypertensive Patients

Abstract

Introduction: During sixth decade of this century Beta adrenoceptor antagonists were developed for the treatment of cardiac arrhythmias and angina pectoris. It was discovered later on that long term treatment with beta blockers caused decrease in arterial blood pressure. Beta adrenergic blocking drugs can be characterized by their pharmacokinetic properties. One property is lipophilic or hydrophilic. Bisoprolol takes an intermediate position between lipophilic and hydrophilic properties of beta blockers. It is readily Conclusion: This placebo controlled single blind study of drug monotherapy for patients with uncomplicated mild to moderate essential hypertension demonstrates that Bisoprolol is an effective, well tolerated and safe means of achieving blood pressure in patients with mild to moderate hypertension who have tolerated the drug well with a dose range of 5 to 10 mg. Adverse effects were mostly mild and discontinuation of Bisoprolol therapy was necessary in only 2 (10%) of patients. Patients had good compliance of drug. Therapy because of single drug regimen.