COMPARISON OF SERUM LIPIDS, LIPOPROTEINS AND APOLIPOPROTEINS IN PATIENTS UNDERGOING CABG WITH HEALTHY ADULTS

Abstract

OBJECTIVE: To assess the pattern of plasma lipoproteins in CAD patients including comparison between diabetic and non-diabetic subgroups. METHODS: This case control study was conducted at National Institute of Cardiovascular Diseases (NICVD) Karachi on patients admitted for CABG from June, 2000 to June, 2001. A total of 100 patients and 100 healthy subjects were enrolled during the study. 38 patients (38%) were diabetic with mean age of 46.16 years and 62 patients (62%) were non-diabetic with mean age of 45.26 years. Serum lipids, apolipoproteins A, apolipoproteins B and Lp(a) of each subject were analysed. One way ANOVA and 95% confidence interval for mean were applied to find the association of CAD with age, BMI, glucose, cholesterol, triacylglycerols, HDL-c, LDL-c, and Lp(a). RESULT: CABG patients had significantly higher blood TAG levels than controls. Similar results were observed for HDL-c, which was significantly lower when compared with control subjects. Apo-B and Lp(a) in controls were significantly lower than both diabetic and non-diabetic CAD patients. The level of Apo-B in diabetic CAD was significantly higher when compared with control subjects.